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Bmi1 Loss in the Organ of Corti Results in p16(ink4a) Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age. The polycomb gene B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) promotes proliferation and cell cycle progression...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068820/ https://ncbi.nlm.nih.gov/pubmed/27755610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164579 |
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