Bmi1 Loss in the Organ of Corti Results in p16(ink4a) Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro

The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age. The polycomb gene B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) promotes proliferation and cell cycle progression...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Bassiouni, Mohamed, Dos Santos, Aurélie, Avci, Hasan X., Löwenheim, Hubert, Müller, Marcus
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068820/
https://ncbi.nlm.nih.gov/pubmed/27755610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164579
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