Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells

The p53-related transcription factor p63 is required for maintenance of epithelial cell differentiation. We found that activated forms of the Harvey Rat Sarcoma Virus GTPase (H-RAS) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) oncogenes strongly repress express...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yoh, Kathryn E., Regunath, Kausik, Guzman, Asja, Lee, Seung-Min, Pfister, Neil T., Akanni, Olutosin, Kaufman, Laura J., Prives, Carol, Prywes, Ron
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068336/
https://ncbi.nlm.nih.gov/pubmed/27681615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613417113
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