The Rho-GTPase Rnd1 Suppresses Mammary Tumorigenesis and EMT by Restraining Ras-MAPK signaling

We identified the Rho-GTPase Rnd1 as a candidate metastasis suppressor through bioinformatics analysis and showed that its depletion disrupt epithelial adhesion and polarity, induced Epithelial-to-Mesenchymal Transition (EMT), and cooperated with deregulated expression of c-Myc or loss of p53 to cau...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Okada, Tomoyo, Sinha, Surajit, Esposito, Ilaria, Schiavon, Gaia, López-Lago, Miguel A., Su, Wenjing, Pratilas, Christine A., Abele, Cristina, Hernandez, Jonathan M., Ohara, Masahiro, Okada, Morihito, Viale, Agnes, Heguy, Adriana, Socci, Nicholas D., Sapino, Anna, Seshan, Venkatraman E., Long, Stephen, Inghirami, Giorgio, Rosen, Neal, Giancotti, Filippo G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374353/
https://ncbi.nlm.nih.gov/pubmed/25531777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3082
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