The Rho-GTPase Rnd1 Suppresses Mammary Tumorigenesis and EMT by Restraining Ras-MAPK signaling

We identified the Rho-GTPase Rnd1 as a candidate metastasis suppressor through bioinformatics analysis and showed that its depletion disrupt epithelial adhesion and polarity, induced Epithelial-to-Mesenchymal Transition (EMT), and cooperated with deregulated expression of c-Myc or loss of p53 to cau...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Cell Biol
मुख्य लेखकों: Okada, Tomoyo, Sinha, Surajit, Esposito, Ilaria, Schiavon, Gaia, López-Lago, Miguel A., Su, Wenjing, Pratilas, Christine A., Abele, Cristina, Hernandez, Jonathan M., Ohara, Masahiro, Okada, Morihito, Viale, Agnes, Heguy, Adriana, Socci, Nicholas D., Sapino, Anna, Seshan, Venkatraman E., Long, Stephen, Inghirami, Giorgio, Rosen, Neal, Giancotti, Filippo G.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2014
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374353/
https://ncbi.nlm.nih.gov/pubmed/25531777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3082
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