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Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling

Integrin signaling promotes, through p21-activated kinase, phosphorylation and inactivation of the tumor suppressor merlin, thus removing a block to mitogenesis in normal cells. However, the biochemical function of merlin and the effector pathways critical for the pathogenesis of malignant mesotheli...

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Detaylı Bibliyografya
Asıl Yazarlar: López-Lago, Miguel A., Okada, Tomoyo, Murillo, Miguel M., Socci, Nick, Giancotti, Filippo G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715795/
https://ncbi.nlm.nih.gov/pubmed/19451229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01578-08
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