RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

The tight spatial coupling of synaptic vesicles and voltage-gated Ca(2+) channels (Ca(V)s) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca(2+) channels and via RIM with oth...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Grauel, M. Katharina, Maglione, Marta, Reddy-Alla, Suneel, Willmes, Claudia G., Brockmann, Marisa M., Trimbuch, Thorsten, Rosenmund, Tanja, Pangalos, Maria, Vardar, Gülçin, Stumpf, Alexander, Walter, Alexander M., Rost, Benjamin R., Eickholt, Britta J., Haucke, Volker, Schmitz, Dietmar, Sigrist, Stephan J., Rosenmund, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068320/
https://ncbi.nlm.nih.gov/pubmed/27671655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605256113
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