RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

The tight spatial coupling of synaptic vesicles and voltage-gated Ca(2+) channels (Ca(V)s) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca(2+) channels and via RIM with oth...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Grauel, M. Katharina, Maglione, Marta, Reddy-Alla, Suneel, Willmes, Claudia G., Brockmann, Marisa M., Trimbuch, Thorsten, Rosenmund, Tanja, Pangalos, Maria, Vardar, Gülçin, Stumpf, Alexander, Walter, Alexander M., Rost, Benjamin R., Eickholt, Britta J., Haucke, Volker, Schmitz, Dietmar, Sigrist, Stephan J., Rosenmund, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068320/
https://ncbi.nlm.nih.gov/pubmed/27671655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605256113
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