Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood

The T-cell receptor (TCR) is required for maturation and function of regulatory T cells (Tregs), but the ligand specificities of Tregs outside the context of transgenic TCRs are largely unknown. Using peptide–MHC tetramers, we isolated rare specific Foxp3(+) cells directly ex vivo from adult periphe...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Su, Laura F., del Alcazar, Daniel, Stelekati, Erietta, Wherry, E. John, Davis, Mark M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068288/
https://ncbi.nlm.nih.gov/pubmed/27681619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611723113
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items