The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells

The RLTPR cytosolic protein, also known as CARMIL2, is essential for CD28 co-stimulation in mice, but its importance in human T cells and mode of action remain elusive. Here, using affinity purification followed by mass spectrometry analysis, we showed that RLTPR acts as a scaffold, bridging CD28 to...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Roncagalli, Romain, Cucchetti, Margot, Jarmuzynski, Nicolas, Grégoire, Claude, Bergot, Elise, Audebert, Stéphane, Baudelet, Emilie, Menoita, Marisa Goncalves, Joachim, Anais, Durand, Stéphane, Suchanek, Miloslav, Fiore, Frédéric, Zhang, Lichen, Liang, Yinming, Camoin, Luc, Malissen, Marie, Malissen, Bernard
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2016
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068240/
https://ncbi.nlm.nih.gov/pubmed/27647348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160579
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