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Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

Declining immune function with age is associated with reduced lymphoid output of hematopoietic stem cells (HSCs). Currently, there is poor understanding of changes with age in the heterogeneous multipotent progenitor (MPP) cell compartment, which is long lived and responsible for dynamically regulat...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Young, Kira, Borikar, Sneha, Bell, Rebecca, Kuffler, Lauren, Philip, Vivek, Trowbridge, Jennifer J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068232/
https://ncbi.nlm.nih.gov/pubmed/27811054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160168
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