Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

Declining immune function with age is associated with reduced lymphoid output of hematopoietic stem cells (HSCs). Currently, there is poor understanding of changes with age in the heterogeneous multipotent progenitor (MPP) cell compartment, which is long lived and responsible for dynamically regulat...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Young, Kira, Borikar, Sneha, Bell, Rebecca, Kuffler, Lauren, Philip, Vivek, Trowbridge, Jennifer J.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068232/
https://ncbi.nlm.nih.gov/pubmed/27811054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160168
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