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BORA-dependent PLK1 regulation: A new weapon for cancer therapy?

The mitotic kinase polo like kinase 1 (PLK1) is overexpressed in many cancers and its inhibition slows down proliferation and increases apoptosis in cancer cell lines. Understanding how PLK1 is activated is therefore crucial for the development of novel PLK1 inhibitors with anticancer properties. We...

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Détails bibliographiques
Publié dans:Mol Cell Oncol
Auteurs principaux: Cirillo, Luca, Thomas, Yann, Pintard, Lionel, Gotta, Monica
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068183/
https://ncbi.nlm.nih.gov/pubmed/27857970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1199265
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