Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos

The molecular mechanisms governing mitotic entry during animal development are incompletely understood. Here, we show that the mitotic kinase CDK-1 phosphorylates Suppressor of Par-Two 1 (SPAT-1)/Bora to regulate its interaction with PLK-1 and to trigger mitotic entry in early Caenorhabditis elegans...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Tavernier, Nicolas, Noatynska, Anna, Panbianco, Costanza, Martino, Lisa, Van Hove, Lucie, Schwager, Françoise, Léger, Thibaut, Gotta, Monica, Pintard, Lionel
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362466/
https://ncbi.nlm.nih.gov/pubmed/25753036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201408064
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