5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

BACKGROUND: Resistance to chemotherapy is a major obstacle in the effective treatment of cancer patients. B7-homolog 1, also known as programmed death ligand-1 (PD-L1), is an immunoregulatory protein that is overexpressed in several human cancers. Interaction of B7-H1 with programmed death 1 (PD-1)...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Van Der Kraak, Lauren, Goel, Gaurav, Ramanan, Krishnaveni, Kaltenmeier, Christof, Zhang, Lin, Normolle, Daniel P., Freeman, Gordon J., Tang, Daolin, Nason, Katie S., Davison, Jon M., Luketich, James D., Dhupar, Rajeev, Lotze, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067917/
https://ncbi.nlm.nih.gov/pubmed/27777774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0163-8
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