Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer

Programmed cell death-1 (PD-1) has demonstrated impressive clinical outcomes in several malignancies, but its therapeutic efficacy in the majority of colorectal cancers is still low. Therefore, methods to improve its therapeutic efficacy in colorectal cancer (CRC) patients need further investigation...

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Detalhes bibliográficos
Main Authors: Kevin Chih-Yang Huang, Shu-Fen Chiang, William Tzu-Liang Chen, Tsung-Wei Chen, Ching-Han Hu, Pei-Chen Yang, Tao-Wei Ke, K. S. Clifford Chao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-02-01
Colecção:Cancers
Assuntos:
colorectal cancer
decitabine
microsatellite instability
anti-pd-l1 immunotherapy
tumor microenvironment
Acesso em linha:https://www.mdpi.com/2072-6694/12/2/462
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