Differential effect of intermittent hypoxia and sleep fragmentation on PD-1/PD-L1 upregulation

Immunosurveillance is compromised in patients with obstructive sleep apnea (OSA) as reflected by overexpression of the programmed death cell receptor and its ligand (PD-1/PD-L1) coinhibitory axis. However, the contributions of intermittent hypoxia (IH) and sleep fragmentation (SF) are unclear. We th...

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Detalhes bibliográficos
Publicado no:Sleep
Main Authors: Cubillos-Zapata, Carolina, Almendros, Isaac, Díaz-García, Elena, Toledano, Victor, Casitas, Raquel, Galera, Raúl, López-Collazo, Eduardo, Farre, Ramón, Gozal, David, García-Rio, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Sleep Disordered Breathing
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7215266/
https://ncbi.nlm.nih.gov/pubmed/31782790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsz285
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