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Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells

Cathepsins are powerful proteases, once referred to as the lysosomal cysteine proteases, that have been implicated in breast cancer invasion and metastasis, but pharmaceutical inhibitors have suffered failures in clinical trials due to adverse side effects. Scientific advancement from lysosomotropic...

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Publicat a:Int J Biochem Cell Biol
Autors principals: Wilder, Catera L., Walton, Charlene, Watson, Valencia, Stewart, Fermin A. A., Johnson, Jade, Peyton, Shelly R., Payne, Christine K., Odero-Marah, Valerie, Platt, Manu O.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067213/
https://ncbi.nlm.nih.gov/pubmed/27592448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2016.08.030
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