TP53 drives invasion through expression of its Δ133p53β variant

TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, based on clinical analysis corroborated with experimen...

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Udgivet i:eLife
Main Authors: Gadea, Gilles, Arsic, Nikola, Fernandes, Kenneth, Diot, Alexandra, Joruiz, Sébastien M, Abdallah, Samer, Meuray, Valerie, Vinot, Stéphanie, Anguille, Christelle, Remenyi, Judit, Khoury, Marie P, Quinlan, Philip R, Purdie, Colin A, Jordan, Lee B, Fuller-Pace, Frances V, de Toledo, Marion, Cren, Maïlys, Thompson, Alastair M, Bourdon, Jean-Christophe, Roux, Pierre
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067115/
https://ncbi.nlm.nih.gov/pubmed/27630122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14734
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