The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer

The RNA helicase p68 is a potent co-activator of p53-dependent transcription in response to DNA damage. Previous independent studies have indicated that p68 and the Δ133p53 isoforms, which modulate the function of full-length p53, are aberrantly expressed in breast cancers. Here we identify a striki...

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Detalhes bibliográficos
Main Authors: Moore, Hayley C, Jordan, Lee B., Bray, Susan E., Baker, Lee, Quinlan, Philip R., Purdie, Colin A, Thompson, Alastair M, Bourdon, Jean-Christophe, Fuller-Pace, Frances V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016604/
https://ncbi.nlm.nih.gov/pubmed/20818423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.381
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