Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell crosspresentation of dead cell-associated antigens

DNGR-1 is a C-type lectin receptor that binds F-actin exposed by dying cells and facilitates cross-presentation of dead cell-associated antigens by dendritic cells. Here we present the structure of DNGR-1 bound to F-actin at 7.7 Å resolution. Unusually for F-actin binding proteins, the DNGR-1 ligand...

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Veröffentlicht in:Immunity
Hauptverfasser: Hanč, Pavel, Fujii, Takashi, Iborra, Salvador, Yamada, Yurika, Huotari, Jatta, Schulz, Oliver, Ahrens, Susan, Kjær, Svend, Way, Michael, Sancho, David, Namba, Keiichi, Reis e Sousa, Caetano
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066845/
https://ncbi.nlm.nih.gov/pubmed/25979418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.04.009
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