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Dissecting the role of Engrailed in adult dopaminergic neurons: Insights into Parkinson disease pathogenesis

The homeoprotein Engrailed (Engrailed-1/Engrailed-2, collectively En1/2) is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. Loss of one En1 allele in the mouse leads t...

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Bibliographic Details
Published in:FEBS Lett
Main Authors: Rekaik, Hocine, Blaudin de Thé, François-Xavier, Prochiantz, Alain, Fuchs, Julia, Joshi, Rajiv L.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066838/
https://ncbi.nlm.nih.gov/pubmed/26459030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.10.002
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