Identification and molecular characterization of cellular factors required for glucocorticoid receptor-mediated mRNA decay

Glucocorticoid (GC) receptor (GR) has been shown recently to bind a subset of mRNAs and elicit rapid mRNA degradation. However, the molecular details of GR-mediated mRNA decay (GMD) remain unclear. Here, we demonstrate that GMD triggers rapid degradation of target mRNAs in a translation-independent...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Park, Ok Hyun, Park, Joori, Yu, Mira, An, Hyoung-Tae, Ko, Jesang, Kim, Yoon Ki
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066615/
https://ncbi.nlm.nih.gov/pubmed/27798850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.286484.116
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