Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

IKAROS is required for the differentiation of highly proliferative pre-B-cell precursors, and loss of IKAROS function indicates poor prognosis in precursor B-cell acute lymphoblastic leukemia (B-ALL). Here we show that IKAROS regulates this developmental stage by positive and negative regulation of...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Hu, Yeguang, Zhang, Zhihong, Kashiwagi, Mariko, Yoshida, Toshimi, Joshi, Ila, Jena, Nilamani, Somasundaram, Rajesh, Emmanuel, Akinola Olumide, Sigvardsson, Mikael, Fitamant, Julien, El-Bardeesy, Nabeel, Gounari, Fotini, Van Etten, Richard A., Georgopoulos, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066240/
https://ncbi.nlm.nih.gov/pubmed/27664237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283762.116
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