Harnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis

Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2β nucleosome remodeling and deacetylase (NuRD) complex was controlled by the Ikaros family of lymphoid-lineage determining proteins. Ikaros, an integral component...

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Autori principali: Zhang, Jiangwen, Jackson, Audrey F., Naito, Taku, Dose, Marei, Seavitt, John, Liu, Feifei, Heller, Elizabeth J., Kashiwagi, Mariko, Yoshida, Toshimi, Gounari, Fotini, Petrie, Howard T., Georgopoulos, Katia
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868219/
https://ncbi.nlm.nih.gov/pubmed/22080921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2150
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