Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis

Loss of Ikaros has been correlated with Notch activation in T cell acute lymphoblastic leukemia (T-ALL), however, the mechanism remains unknown. We identified promoters in Notch1 that drive expression of Notch1 proteins active in the absence of ligand. Ikaros bound to both canonical and alternative...

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Main Authors: Gómez-del Arco, Pablo, Kashiwagi, Mariko, Jackson, Audrey F., Naito, Taku, Zhang, Jiangwen, Liu, Feifei, Kee, Barbara, Vooijs, Marc, Radtke, Freddy, Redondo, Juan Miguel, Georgopoulos, Katia
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072037/
https://ncbi.nlm.nih.gov/pubmed/21093322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.008
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