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Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis
Loss of Ikaros has been correlated with Notch activation in T cell acute lymphoblastic leukemia (T-ALL), however, the mechanism remains unknown. We identified promoters in Notch1 that drive expression of Notch1 proteins active in the absence of ligand. Ikaros bound to both canonical and alternative...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072037/ https://ncbi.nlm.nih.gov/pubmed/21093322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.008 |
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