Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in...

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Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066238/
https://ncbi.nlm.nih.gov/pubmed/27633013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283499.116
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