Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066238/
https://ncbi.nlm.nih.gov/pubmed/27633013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283499.116
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