Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066238/
https://ncbi.nlm.nih.gov/pubmed/27633013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283499.116
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