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Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors

[Image: see text] Dual inhibition of PI3K-δ and PI3K-γ is an established therapeutic strategy for treatment of hematological malignancies. Reported molecules targeting PI3K-δ/γ selectively are chemically similar and based upon isoquinolin-1(2H)-one or quinazolin-4(3H)-one scaffolds. Here we report a...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Ferguson, Fleur M., Ni, Jing, Zhang, Tinghu, Tesar, Bethany, Sim, Taebo, Kim, Nam Doo, Deng, Xianming, Brown, Jennifer R., Zhao, Jean J., Gray, Nathanael S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066161/
https://ncbi.nlm.nih.gov/pubmed/27774127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00209
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