טוען...
Development of a Potent and Selective HDAC8 Inhibitor
[Image: see text] A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
שמור ב:
| הוצא לאור ב: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2016
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5066159/ https://ncbi.nlm.nih.gov/pubmed/27774131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00239 |
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