Development of a Potent and Selective HDAC8 Inhibitor

[Image: see text] A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Ingham, Oscar J., Paranal, Ronald M., Smith, William B., Escobar, Randolph A., Yueh, Han, Snyder, Tracy, Porco, John A., Bradner, James E., Beeler, Aaron B.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066159/
https://ncbi.nlm.nih.gov/pubmed/27774131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00239
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