Combined Interactions with I(1)-, I(2)-Imidazoline Binding Sites and α(2)-Adrenoceptors To Manage Opioid Addiction

[Image: see text] Tolerance and dependence associated with chronic opioid exposure result from molecular, cellular, and neural network adaptations. Such adaptations concern opioid and nonopioid systems, including α(2)-adrenoceptors (α(2)-ARs) and I(1)- and I(2)-imidazoline binding sites (IBS). Agmat...

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Foilsithe in:ACS Med Chem Lett
Main Authors: Giusepponi, Maria Elena, Cifani, Carlo, Micioni Di Bonaventura, Maria Vittoria, Mattioli, Laura, Hudson, Alan, Diamanti, Eleonora, Del Bello, Fabio, Giannella, Mario, Mammoli, Valerio, Paoletti, Corinne Dalila, Piergentili, Alessandro, Pigini, Maria, Quaglia, Wilma
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2016
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066154/
https://ncbi.nlm.nih.gov/pubmed/27774136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00290
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