Combined Interactions with I(1)-, I(2)-Imidazoline Binding Sites and α(2)-Adrenoceptors To Manage Opioid Addiction

[Image: see text] Tolerance and dependence associated with chronic opioid exposure result from molecular, cellular, and neural network adaptations. Such adaptations concern opioid and nonopioid systems, including α(2)-adrenoceptors (α(2)-ARs) and I(1)- and I(2)-imidazoline binding sites (IBS). Agmat...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Giusepponi, Maria Elena, Cifani, Carlo, Micioni Di Bonaventura, Maria Vittoria, Mattioli, Laura, Hudson, Alan, Diamanti, Eleonora, Del Bello, Fabio, Giannella, Mario, Mammoli, Valerio, Paoletti, Corinne Dalila, Piergentili, Alessandro, Pigini, Maria, Quaglia, Wilma
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066154/
https://ncbi.nlm.nih.gov/pubmed/27774136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00290
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