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Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia
Dysregulation of mRNA translation leads to aberrant activation of cellular pathways that promote expansion and survival of leukemic clones. A key element of the initiation translation complex is eIF4E (eukaryotic translation initiation factor 4E). The mitogen-activated protein kinase (MAPK) and mamm...
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| Veröffentlicht in: | Cytokine |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5065931/ https://ncbi.nlm.nih.gov/pubmed/27094611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2016.01.024 |
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