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Proton currents constrain structural models of voltage sensor activation
The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H(+) conductance (G(AQ)). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H(+) ‘shuttle’ conductance (G(SH)) in VGCs and Ci VSP, an...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5065317/ https://ncbi.nlm.nih.gov/pubmed/27572256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18017 |
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