MyD88/CD40 Genetic Adjuvant Function in Cutaneous Atypical Antigen-Presenting Cells Contributes to DNA Vaccine Immunogenicity

Therapeutic DNA-based vaccines aim to prime an adaptive host immune response against tumor-associated antigens, eliminating cancer cells primarily through CD8(+) cytotoxic T cell-mediated destruction. To be optimally effective, immunological adjuvants are required for the activation of tumor-specifi...

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Vydáno v:PLoS One
Hlavní autoři: Collinson-Pautz, Matthew R., Slawin, Kevin M., Levitt, Jonathan M., Spencer, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065236/
https://ncbi.nlm.nih.gov/pubmed/27741278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164547
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