Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development

BACKGROUND: Neural tube defects (NTDs) are severe congenital malformations that arise from failure of neurulation during early embryonic development. The molecular basis underlying most human NTDs still remains largely unknown. Based on the hypothesis that folic acid prevents NTDs by stimulating met...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Rochtus, Anne, Winand, Raf, Laenen, Griet, Vangeel, Elise, Izzi, Benedetta, Wittevrongel, Christine, Moreau, Yves, Verpoorten, Carla, Jansen, Katrien, Van Geet, Chris, Freson, Kathleen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064967/
https://ncbi.nlm.nih.gov/pubmed/27757173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0272-8
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