Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development

BACKGROUND: Neural tube defects (NTDs) are severe congenital malformations that arise from failure of neurulation during early embryonic development. The molecular basis underlying most human NTDs still remains largely unknown. Based on the hypothesis that folic acid prevents NTDs by stimulating met...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Rochtus, Anne, Winand, Raf, Laenen, Griet, Vangeel, Elise, Izzi, Benedetta, Wittevrongel, Christine, Moreau, Yves, Verpoorten, Carla, Jansen, Katrien, Van Geet, Chris, Freson, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064967/
https://ncbi.nlm.nih.gov/pubmed/27757173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0272-8
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