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N-terminal Prion Protein Peptides (PrP(120–144)) Form Parallel In-register β-Sheets via Multiple Nucleation-dependent Pathways

The prion diseases are a family of fatal neurodegenerative diseases associated with the misfolding and accumulation of normal prion protein (PrP(C)) into its pathogenic scrapie form (PrP(Sc)). Understanding the fundamentals of prion protein aggregation and the molecular architecture of PrP(Sc) is ke...

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Pubblicato in:J Biol Chem
Autori principali: Wang, Yiming, Shao, Qing, Hall, Carol K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063992/
https://ncbi.nlm.nih.gov/pubmed/27576687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.744573
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