Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE

Renal cells of the thick ascending limb (TAL) reabsorb NaCl via the apical Na(+)/K(+)/2Cl(−) co-transporter NKCC2. Trafficking of NKCC2 to the apical surface regulates NKCC2-mediated NaCl absorption and blood pressure. The molecular mechanisms by which NKCC2 reaches the apical surface and their role...

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Vydáno v:J Biol Chem
Hlavní autoři: Caceres, Paulo S., Mendez, Mariela, Haque, Mohammed Z., Ortiz, Pablo A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063989/
https://ncbi.nlm.nih.gov/pubmed/27551042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735167
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