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Vesicle-associated Membrane Protein 2 (VAMP2) but Not VAMP3 Mediates cAMP-stimulated Trafficking of the Renal Na(+)-K(+)-2Cl(−) Co-transporter NKCC2 in Thick Ascending Limbs

In the kidney, epithelial cells of the thick ascending limb (TAL) reabsorb NaCl via the apical Na(+)/K(+)/2Cl(−) co-transporter NKCC2. Steady-state surface NKCC2 levels in the apical membrane are maintained by a balance between exocytic delivery, endocytosis, and recycling. cAMP is the second messen...

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Bibliographische Detailangaben
Hauptverfasser: Caceres, Paulo S., Mendez, Mariela, Ortiz, Pablo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156046/
https://ncbi.nlm.nih.gov/pubmed/25008321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589333
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