Interdomain Conformational Changes Provide Allosteric Regulation en Route to Chorismate

Multifunctional proteins play a variety of roles in metabolism. Here, we examine the catalytic function of the combined 3-deoxy-d-arabino heptulosonate-7-phosphate synthase (DAH7PS) and chorismate mutase (CM) from Geobacillus sp. DAH7PS operates at the start of the biosynthetic pathway for aromatic...

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Publicat a:J Biol Chem
Autors principals: Nazmi, Ali Reza, Lang, Eric J. M., Bai, Yu, Allison, Timothy M., Othman, Mohamad H., Panjikar, Santosh, Arcus, Vickery L., Parker, Emily J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063969/
https://ncbi.nlm.nih.gov/pubmed/27502275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741637
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