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The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

The small GTPase Rab5 promotes recruitment of the Ccz1-Mon1 guanosine exchange complex to endosomes to activate Rab7, which facilitates endosome maturation and fusion with lysosomes. How these factors function during autophagy is incompletely understood. Here we show that autophagosomes accumulate d...

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Publicado en:Mol Biol Cell
Autores principales: Hegedűs, Krisztina, Takáts, Szabolcs, Boda, Attila, Jipa, András, Nagy, Péter, Varga, Kata, Kovács, Attila L., Juhász, Gábor
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063620/
https://ncbi.nlm.nih.gov/pubmed/27559127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-03-0205
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