High Potency VEGFRs/MET/FMS Triple Blockade by TAS-115 Concomitantly Suppresses Tumor Progression and Bone Destruction in Tumor-Induced Bone Disease Model with Lung Carcinoma Cells

Approximately 25–40% of patients with lung cancer show bone metastasis. Bone modifying agents reduce skeletal-related events (SREs), but they do not significantly improve overall survival. Therefore, novel therapeutic approaches are urgently required. In this study, we investigated the anti-tumor ef...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fujita, Hidenori, Gomori, Akira, Fujioka, Yayoi, Kataoka, Yuki, Tanaka, Kenji, Hashimoto, Akihiro, Suzuki, Takamasa, Ito, Kenjiro, Haruma, Tomonori, Yamamoto-Yokoi, Hiromi, Harada, Naomoto, Sakuragi, Motomu, Oda, Nobuyuki, Matsuo, Kenichi, Inada, Masaki, Yonekura, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063576/
https://ncbi.nlm.nih.gov/pubmed/27736957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164830
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