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Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells
Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6–10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN protein that are observed in SMA have been shown to result in aberrant mRNA spl...
Tallennettuna:
| Julkaisussa: | PLoS One |
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| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063418/ https://ncbi.nlm.nih.gov/pubmed/27736905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163954 |
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