Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells

Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6–10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN protein that are observed in SMA have been shown to result in aberrant mRNA spl...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Custer, Sara K., Gilson, Timra D., Li, Hongxia, Todd, A. Gary, Astroski, Jacob W., Lin, Hai, Liu, Yunlong, Androphy, Elliot J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063418/
https://ncbi.nlm.nih.gov/pubmed/27736905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163954
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker