Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells

Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6–10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN protein that are observed in SMA have been shown to result in aberrant mRNA spl...

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Bibliographic Details
Published in:PLoS One
Main Authors: Custer, Sara K., Gilson, Timra D., Li, Hongxia, Todd, A. Gary, Astroski, Jacob W., Lin, Hai, Liu, Yunlong, Androphy, Elliot J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063418/
https://ncbi.nlm.nih.gov/pubmed/27736905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163954
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