Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells

Spinal muscular atrophy (SMA) is an intractable neurodegenerative disease afflicting 1 in 6–10,000 live births. One of the key functions of the SMN protein is regulation of spliceosome assembly. Reduced levels of the SMN protein that are observed in SMA have been shown to result in aberrant mRNA spl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Custer, Sara K., Gilson, Timra D., Li, Hongxia, Todd, A. Gary, Astroski, Jacob W., Lin, Hai, Liu, Yunlong, Androphy, Elliot J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063418/
https://ncbi.nlm.nih.gov/pubmed/27736905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163954
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