Interaction between alpha-COP and SMN ameliorates disease phenotype in a mouse model of Spinal Muscular Atrophy

We report that expression of the α-COP protein rescues disease phenotype in a severe mouse model of Spinal Muscular Atrophy (SMA).. Lentiviral particles expressing α-COP were injected directly into the testes of genetically pure mouse strain of interest resulting in infection of the spermatagonial s...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Custer, Sara K, Astroski, Jacob W, Li, Hong Xia, Androphy, Elliot J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068134/
https://ncbi.nlm.nih.gov/pubmed/31060774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.04.176
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