Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN‐I responses

Acute or chronic viral infections can lead to generalized immunosuppression. Several mechanisms, such as immunopathology of CD8(+) T cells, inhibitory receptors, or regulatory T (Treg) cells, contribute to immune dysfunction. Moreover, patients with chronic viral infections usually do not respond to...

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Vydáno v:Eur J Immunol
Hlavní autoři: Honke, Nadine, Shaabani, Namir, Merches, Katja, Gassa, Asmae, Kraft, Anke, Ehrhardt, Katrin, Häussinger, Dieter, Löhning, Max, Dittmer, Ulf, Hengel, Hartmut, Recher, Mike, Lang, Philipp A., Lang, Karl S.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Immunity to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063111/
https://ncbi.nlm.nih.gov/pubmed/26507703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545765
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