Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN‐I responses

Acute or chronic viral infections can lead to generalized immunosuppression. Several mechanisms, such as immunopathology of CD8(+) T cells, inhibitory receptors, or regulatory T (Treg) cells, contribute to immune dysfunction. Moreover, patients with chronic viral infections usually do not respond to...

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Bibliografski detalji
Izdano u:Eur J Immunol
Glavni autori: Honke, Nadine, Shaabani, Namir, Merches, Katja, Gassa, Asmae, Kraft, Anke, Ehrhardt, Katrin, Häussinger, Dieter, Löhning, Max, Dittmer, Ulf, Hengel, Hartmut, Recher, Mike, Lang, Philipp A., Lang, Karl S.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Immunity to Infection
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063111/
https://ncbi.nlm.nih.gov/pubmed/26507703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545765
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