Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN‐I responses

Acute or chronic viral infections can lead to generalized immunosuppression. Several mechanisms, such as immunopathology of CD8(+) T cells, inhibitory receptors, or regulatory T (Treg) cells, contribute to immune dysfunction. Moreover, patients with chronic viral infections usually do not respond to...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Honke, Nadine, Shaabani, Namir, Merches, Katja, Gassa, Asmae, Kraft, Anke, Ehrhardt, Katrin, Häussinger, Dieter, Löhning, Max, Dittmer, Ulf, Hengel, Hartmut, Recher, Mike, Lang, Philipp A., Lang, Karl S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Immunity to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063111/
https://ncbi.nlm.nih.gov/pubmed/26507703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545765
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