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Copper-Catalyzed Asymmetric Addition of Olefin-Derived Nucleophiles to Ketones

Enantioenriched alcohols found in an array of bioactive natural products and pharmaceutical agents are often synthesized by asymmetric nucleophilic addition to carbonyls. However, this approach generally shows limited functional group compatibility, requiring the use of preformed organometallic reag...

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Dades bibliogràfiques
Publicat a:Science
Autors principals: Yang, Yang, Perry, Ian B., Lu, Gang, Liu, Peng, Buchwald, Stephen L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062742/
https://ncbi.nlm.nih.gov/pubmed/27284169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf7720
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