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Copper-Catalyzed Asymmetric Addition of Olefin-Derived Nucleophiles to Ketones

Enantioenriched alcohols found in an array of bioactive natural products and pharmaceutical agents are often synthesized by asymmetric nucleophilic addition to carbonyls. However, this approach generally shows limited functional group compatibility, requiring the use of preformed organometallic reag...

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Vydáno v:Science
Hlavní autoři: Yang, Yang, Perry, Ian B., Lu, Gang, Liu, Peng, Buchwald, Stephen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062742/
https://ncbi.nlm.nih.gov/pubmed/27284169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf7720
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